Dataset Information

Sphingosine-1-phosphate receptor-1 (S1P₁) is expressed by lymphocytes, dendritic cells, and endothelium and modulated during inflammatory bowel disease.

ABSTRACT: The sphingosine-1-phosphate receptor-1 (S1P₁) agonist ozanimod ameliorates ulcerative colitis, yet its mechanism of action is unknown. Here, we examine the cell subsets that express S1P₁ in intestine using S1P₁-eGFP mice, the regulation of S1P₁ expression in lymphocytes after administration of dextran sulfate sodium (DSS), after colitis induced by transfer of CD4⁺CD45RB^hi cells, and by crossing a mouse with TNF-driven ileitis with S1P₁-eGFP mice. We then assayed the expression of enzymes that regulate intestinal S1P levels, and the effect of FTY720 on lymphocyte behavior and S1P₁ expression. We found that not only T and B cells express S1P₁, but also dendritic (DC) and endothelial cells. Furt

SUBMITTER: Karuppuchamy T

PROVIDER: S-EPMC5053832 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature

ACCESS DATA

Dataset Information

Sphingosine-1-phosphate receptor-1 (S1P₁) is expressed by lymphocytes, dendritic cells, and endothelium and modulated during inflammatory bowel disease.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Sphingosine-1-phosphate receptor-1 (S1P1) is expressed by lymphocytes, dendritic cells, and endothelium and modulated during inflammatory bowel disease.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Sphingosine-1-phosphate receptor-1 (S1P₁) is expressed by lymphocytes, dendritic cells, and endothelium and modulated during inflammatory bowel disease.