Macrophage migration inhibitory factor deficiency enhances immune response to Nippostrongylus brasiliensis.

ABSTRACT: Infections with helminth parasites are endemic in the developing world and are a target for intervention with new therapies. Macrophage migration inhibitory factor (MIF) is a cytokine with pleiotropic effects in inflammation and immune responses. We investigated the role of MIF in a naturally cleared model of helminth infection in rodents, Nippostrongylus brasiliensis. At day 7 postinfection, MIF-deficient (MIF^-/-) mice had reduced parasite burden and mounted an enhanced type 2 immune response (Th2), including increased Gata3 expression and interleukin-13 (IL-13) production in the mesenteric lymph nodes (MLNs). Bone marrow reconstitution demonstrated that MIF produced from hematopoietic cells was crucial and Rag1^-/- reconstitution provided direct evidence that MIF

SUBMITTER: Damle SR 

PROVIDER: S-EPMC5053838 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature