Ser(P)-1292 LRRK2 in urinary exosomes is elevated in idiopathic Parkinson's disease.

ABSTRACT:

Background

Mutations in Leucine-rich repeat kinase 2 (LRRK2) enhance levels of the autophosphorylated LRRK2 protein and are the most common known cause of inherited Parkinson's disease (PD). LRRK2 has been further implicated in susceptibility to idiopathic PD in genetic association studies.

Objective

The objective of this study was to compare autophosphorylated Ser(P)-1292 LRRK2 levels from biobanked urine samples with clinical data in PD patients and controls.

Methods

Ser(P)-1292 LRRK2 levels were measured from urine exosome fractions from 79 PD patients and 79 neurologically healthy controls enrolled in the Parkinson Disease Biomarker Program at the University of Alabama at Birmingham.

Results

Ser(P)-1292 LRRK2 levels were higher in men than women (P < .0001)

SUBMITTER: Fraser KB 

PROVIDER: S-EPMC5053851 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature