Neuroanatomical and neurofunctional markers of social cognition in autism spectrum disorder.

ABSTRACT: Social impairments in autism spectrum disorder (ASD), a hallmark feature of its diagnosis, may underlie specific neural signatures that can aid in differentiating between those with and without ASD. To assess common and consistent patterns of differences in brain responses underlying social cognition in ASD, this study applied an activation likelihood estimation (ALE) meta-analysis to results from 50 neuroimaging studies of social cognition in children and adults with ASD. In addition, the group ALE clusters of activation obtained from this was used as a social brain mask to perform surface-based cortical morphometry (SBM) in an empirical structural MRI dataset collected from 55 ASD and 60 typically developing (TD) control participants. Overall, the ALE meta-analysis revealed consistent di

SUBMITTER: Patriquin MA 

PROVIDER: S-EPMC5053857 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature