Brain activity and connectivity in response to negative affective stimuli: Impact of dysphoric mood and sex across diagnoses.

ABSTRACT: Negative affective stimuli elicit behavioral and neural responses which vary on a continuum from adaptive to maladaptive, yet are typically investigated in a dichotomous manner (healthy controls vs. psychiatric diagnoses). This practice may limit our ability to fully capture variance from acute responses to negative affective stimuli to psychopathology at the extreme end. To address this, we conducted a functional magnetic resonance imaging study to examine the neural responses to negative valence/high arousal and neutral valence/low arousal images as a function of dysphoric mood and sex across individuals (n = 99) who represented traditional categories of healthy controls, major depressive disorder, bipolar psychosis, and schizophrenia. Observation of negative (vs. neutral) stimuli elicit

SUBMITTER: Mareckova K 

PROVIDER: S-EPMC5053909 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature