Psoriasis-Specific RNA Isoforms Identified by RNA-Seq Analysis of 173,446 Transcripts.

ABSTRACT:

Background

Several studies have been published that investigated potential links between transcriptome changes and psoriasis using microarrays and RNA-seq technologies, but no previous study has analyzed expression profile of alternatively spliced transcripts in psoriasis.

Objectives

Identification of potential alternatively spliced RNA isoforms with disease-specific expression profile.

Methods

Using our published RNA sequencing data from lesional psoriatic (LP), non-lesional psoriatic (NLP), and normal control skin (C), we analyzed the differential expression of RNA splicing variants. LP sample was compared with NLP, as was LP with C and NLP with C.

Results

Transcript-based annotation analyzed 173,446 transcripts (RNA isoforms), and around 9,000 transcripts we

SUBMITTER: Koks S 

PROVIDER: S-EPMC5053979 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature