Differential transcriptional responses to Ebola and Marburg virus infection in bat and human cells.

ABSTRACT: The unprecedented outbreak of Ebola in West Africa resulted in over 28,000 cases and 11,000 deaths, underlining the need for a better understanding of the biology of this highly pathogenic virus to develop specific counter strategies. Two filoviruses, the Ebola and Marburg viruses, result in a severe and often fatal infection in humans. However, bats are natural hosts and survive filovirus infections without obvious symptoms. The molecular basis of this striking difference in the response to filovirus infections is not well understood. We report a systematic overview of differentially expressed genes, activity motifs and pathways in human and bat cells infected with the Ebola and Marburg viruses, and we demonstrate that the replication of filoviruses is more rapid in human cells than in ba

SUBMITTER: Holzer M 

PROVIDER: S-EPMC5054393 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature