B-cell ligand processing pathways detected by large-scale comparative analysis.

ABSTRACT: The initiation of B-cell ligand recognition is a critical step for the generation of an immune response against foreign bodies. We sought to identify the biochemical pathways involved in the B-cell ligand recognition cascade and sets of ligands that trigger similar immunological responses. We utilized several comparative approaches to analyze the gene coexpression networks generated from a set of microarray experiments spanning 33 different ligands. First, we compared the degree distributions of the generated networks. Second, we utilized a pairwise network alignment algorithm, BiNA, to align the networks based on the hubs in the networks. Third, we aligned the networks based on a set of KEGG pathways. We summarized our results by constructing a consensus hierarchy of pathways that are inv

SUBMITTER: Towfic F 

PROVIDER: S-EPMC5054497 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature