CDS: a fold-change based statistical test for concomitant identification of distinctness and similarity in gene expression analysis.

ABSTRACT: The problem of identifying differential activity such as in gene expression is a major defeat in biostatistics and bioinformatics. Equally important, however much less frequently studied, is the question of similar activity from one biological condition to another. The fold-change, or ratio, is usually considered a relevant criterion for stating difference and similarity between measurements. Importantly, no statistical method for concomitant evaluation of similarity and distinctness currently exists for biological applications. Modern microarray, digital PCR (dPCR), and Next-Generation Sequencing (NGS) technologies frequently provide a means of coefficient of variation estimation for individual measurements. Using fold-change, and by making the assumption that measurements are normally di

SUBMITTER: Tchitchek N 

PROVIDER: S-EPMC5054499 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature