TrFAST: a tool to predict signaling pathway-specific transcription factor binding sites.

ABSTRACT: Recent advances in the development of high-throughput tools have significantly revolutionized our understanding of molecular mechanisms underlying normal and dysfunctional biological processes. Here we present a novel computational tool, transcription factor search and analysis tool (TrFAST), which was developed for the in silico analysis of transcription factor binding sites (TFBSs) of signaling pathway-specific TFs. TrFAST facilitates searching as well as comparative analysis of regulatory motifs through an exact pattern matching algorithm followed by the graphical representation of matched binding sites in multiple sequences up to 50kb in length. TrFAST is proficient in reducing the number of comparisons by the exact pattern matching strategy. In contrast to the pre-existing tools that

SUBMITTER: Seemab U 

PROVIDER: S-EPMC5054711 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature