Novel adaptors of amyloid precursor protein intracellular domain and their functional implications.

ABSTRACT: Amyloid precursor protein intracellular domain (AICD) is one of the potential candidates in deciphering the complexity of Alzheimer's disease. It plays important roles in determining cell fate and neurodegeneration through its interactions with several adaptors. The presence or absence of phosphorylation at specific sites determines the choice of partners. In this study, we identified 20 novel AICD-interacting proteins by in vitro pull down experiments followed by 2D gel electrophoresis and MALDI-MS analysis. The identified proteins can be grouped into different functional classes including molecular chaperones, structural proteins, signaling and transport molecules, adaptors, motor proteins and apoptosis determinants. Interactions of nine proteins were further validated either by colocali

SUBMITTER: Chakrabarti A 

PROVIDER: S-EPMC5054717 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature