Rapid, Dynamic Activation of Muller Glial Stem Cell Responses in Zebrafish.

ABSTRACT:

Purpose

Zebrafish neurons regenerate from Müller glia following retinal lesions. Genes and signaling pathways important for retinal regeneration in zebrafish have been described, but our understanding of how Müller glial stem cell properties are regulated is incomplete. Mammalian Müller glia possess a latent neurogenic capacity that might be enhanced in regenerative therapies to treat degenerative retinal diseases.

Methods

To identify transcriptional changes associated with stem cell properties in zebrafish Müller glia, we performed a comparative transcriptome analysis from isolated cells at 8 and 16 hours following an acute photic lesion, prior to the asymmetric division that produces retinal progenitors.

Results

We report a rapid, dynamic response of zebrafish Mülle

SUBMITTER: Sifuentes CJ 

PROVIDER: S-EPMC5054728 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature