In Vivo Brillouin Analysis of the Aging Crystalline Lens.

ABSTRACT:

Purpose

To analyze the age dependence of the longitudinal modulus of the crystalline lens in vivo using Brillouin scattering data in healthy subjects.

Methods

Brillouin scans were performed along the crystalline lens in 56 eyes from 30 healthy subjects aged from 19 to 63 years. Longitudinal elastic modulus was acquired along the sagittal axis of the lens with a transverse and axial resolution of 4 and 60 μm, respectively. The relative lens stiffness was computed, and correlations with age were analyzed.

Results

Brillouin axial profiles revealed nonuniform longitudinal modulus within the lens, increasing from a softer periphery toward a stiffer central plateau at all ages. The longitudinal modulus at the central plateau showed no age dependence in a range of 19 to 45 y

SUBMITTER: Besner S 

PROVIDER: S-EPMC5054731 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature