Loss of Axin2 Causes Ocular Defects During Mouse Eye Development.

ABSTRACT:

Purpose

The scaffold protein Axin2 is an antagonist and universal target of the Wnt/β-catenin pathway. Disruption of Axin2 may lead to developmental eye defects; however, this has not been examined. The purpose of this study was to investigate the role of Axin2 during ocular and extraocular development in mouse.

Methods

Animals heterozygous and homozygous for a Axin2lacZ knock-in allele were analyzed at different developmental stages for reporter expression, morphology as well as for the presence of ocular and extraocular markers using histologic and immunohistochemical techniques.

Results

During early eye development, the Axin2lacZ reporter was expressed in the periocular mesenchyme, RPE, and optic stalk. In the developing retina, Axin2lacZ reporter expression was in

SUBMITTER: Alldredge A 

PROVIDER: S-EPMC5054732 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature