Analysis of Microstructure of the Cardiac Conduction System Based on Three-Dimensional Confocal Microscopy.

ABSTRACT: The specialised conducting tissues present in the ventricles are responsible for the fast distribution of the electrical impulse from the atrio-ventricular node to regions in the subendocardial myocardium. Characterisation of anatomical features of the specialised conducting tissues in the ventricles is highly challenging, in particular its most distal section, which is connected to the working myocardium via Purkinje-myocardial junctions. The goal of this work is to characterise the architecture of the distal section of the Purkinje network by differentiating Purkinje cells from surrounding tissue, performing a segmentation of Purkinje fibres at cellular scale, and mathematically describing its morphology and interconnections. Purkinje cells from rabbit hearts were visualised by confocal

SUBMITTER: Romero D 

PROVIDER: S-EPMC5055359 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature