Targeted multimodal nano-reporters for pre-procedural MRI and intra-operative image-guidance.

ABSTRACT: Multimodal-imaging probes offer a novel approach, which can provide detail diagnostic information for the planning of image-guided therapies in clinical practice. Here we report targeted multimodal Nd³⁺-doped upconversion nanoparticle (UCNP) imaging reporters, integrating both magnetic resonance imaging (MRI) and real-time upconversion luminescence imaging (UCL) capabilities within a single platform. Nd³⁺-doped UCNPs were synthesized as a core-shell structure showing a bright visible emission upon excitation at the near infrared (minimizing biological overheating and increasing tissue penetration depth) as well as providing strong MRI T2 contrast (high r₂/r₁ ratio). Transcatheter intra-arterial infusion of Nd³⁺-doped UCNPs conjugated w

SUBMITTER: Lee J 

PROVIDER: S-EPMC5055467 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature