Plate-based diversity subset screening generation 2: an improved paradigm for high-throughput screening of large compound files.

ABSTRACT: High-throughput screening (HTS) is an effective method for lead and probe discovery that is widely used in industry and academia to identify novel chemical matter and to initiate the drug discovery process. However, HTS can be time consuming and costly and the use of subsets as an efficient alternative to screening entire compound collections has been investigated. Subsets may be selected on the basis of chemical diversity, molecular properties, biological activity diversity or biological target focus. Previously, we described a novel form of subset screening: plate-based diversity subset (PBDS) screening, in which the screening subset is constructed by plate selection (rather than individual compound cherry-picking), using algorithms that select for compound quality and chemical diversity

SUBMITTER: Bell AS 

PROVIDER: S-EPMC5055576 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature