Cystatin C and Objectively Measured Mobility 10 Years Later in Older Women.

ABSTRACT:

Background

Serum biomarkers predicting physical performance in late life are uncertain. We tested the hypotheses that lower serum cystatin C (cysC) in older women is associated with good mobility 10 years later.

Methods

We conducted a longitudinal analysis of a prospective cohort of 1,384 women attending Year 10 and Year 20 examinations of the Study of Osteoporotic Fractures. Serum cysC was measured using Year 10 frozen serum specimens. Year 20 mobility was ascertained by the Short Physical Performance Battery; scores of 10-12 indicated good mobility.

Results

At Year 20, mean age was 87.5 years and 364 women (26.3%) had good mobility. After adjustment for age, race, education, health status, diabetes, cardiovascular disease, and body mass index, lower cysC at Year 10

SUBMITTER: Ensrud KE 

PROVIDER: S-EPMC5055645 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature