Effect of Statin Use on Mobility Disability and its Prevention in At-risk Older Adults: The LIFE Study.

ABSTRACT:

Background

HMG-CoA reductase inhibitors (statins) are among the most commonly prescribed classes of medications. Although their cardiovascular benefits and myalgia risks are well documented, their effects on older adults initiating an exercise training program are less understood.

Methods

1,635 sedentary men and women aged 70-89 years with Short Physical Performance Battery (SPPB) score of 9 or below and were able to walk 400 m were randomized to a structured, moderate-intensity physical activity (PA) program consisting of both center-based (twice/wk) and home-based (3-4 times/wk) aerobic, resistance, and flexibility training or to a health education (HE) program combined with upper extremity stretching.

Results

Overall, the PA intervention was associated with lower r

SUBMITTER: Henderson RM 

PROVIDER: S-EPMC5055646 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature