Frameworks for Proof-of-Concept Clinical Trials of Interventions That Target Fundamental Aging Processes.

ABSTRACT: Therapies targeted at fundamental processes of aging may hold great promise for enhancing the health of a wide population by delaying or preventing a range of age-related diseases and conditions-a concept dubbed the "geroscience hypothesis." Early, proof-of-concept clinical trials will be a key step in the translation of therapies emerging from model organism and preclinical studies into clinical practice. This article summarizes the outcomes of an international meeting partly funded through the NIH R24 Geroscience Network, whose purpose was to generate concepts and frameworks for early, proof-of-concept clinical trials for therapeutic interventions that target fundamental processes of aging. The goals of proof-of-concept trials include generating preliminary signals of efficacy in an agin

SUBMITTER: Justice J 

PROVIDER: S-EPMC5055651 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature