Strategies and Challenges in Clinical Trials Targeting Human Aging.

ABSTRACT: Interventions that target fundamental aging processes have the potential to transform human health and health care. A variety of candidate drugs have emerged from basic and translational research that may target aging processes. Some of these drugs are already in clinical use for other purposes, such as metformin and rapamycin. However, designing clinical trials to test interventions that target the aging process poses a unique set of challenges. This paper summarizes the outcomes of an international meeting co-ordinated by the NIH-funded Geroscience Network to further the goal of developing a translational pipeline to move candidate compounds through clinical trials and ultimately into use. We review the evidence that some drugs already in clinical use may target fundamental aging process

SUBMITTER: Newman JC 

PROVIDER: S-EPMC5055653 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature