Association Analysis of FOXO3 Longevity Variants With Blood Pressure and Essential Hypertension.

ABSTRACT:

Background

The minor alleles of 3 FOXO3 single nucleotide polymorphisms (SNPs)- rs2802292 , rs2253310 , and rs2802288 -are associated with human longevity. The aim of the present study was to test these SNPs for association with blood pressure (BP) and essential hypertension (EHT).

Methods

In a primary study involving Americans of Japanese ancestry drawn from the Family Blood Pressure Program II we genotyped 411 female and 432 male subjects aged 40-79 years and tested for statistical association by contingency table analysis and generalized linear models that included logistic regression adjusting for sibling correlation in the data set. Replication of rs2802292 with EHT was attempted in Japanese SONIC study subjects and of each SNP in a meta-analysis of genome-wide associat

SUBMITTER: Morris BJ 

PROVIDER: S-EPMC5055732 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature