Alanine to Serine Variant at Position 986 of Calcium Sensing Receptor and Colorectal Cancer Risk.

ABSTRACT:

Background

With regard to the effect of calcium against colorectal cancer (CRC) and considering the key role of calcium sensing receptor (CaSR) in calcium homeostasis, this study investigated whether CaSR gene rs1801725 or A986S variant was associated with susceptibility to CRC risk.

Methods

This study was conducted as a case-control study and 303 cases with CRC and 354 controls were enrolled. All 657 subjects were genotyped for CaSR gene A986S variant using PCR-RFLP method.

Results

No significant difference was observed for the A986S variant of CaSR gene in either genotype or allele frequencies between the cases and the controls and this lack of difference remained non-significant even after adjustment for age, BMI, sex, smoking status, and famil

SUBMITTER: Dabiri R 

PROVIDER: S-EPMC5056015 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature