Negative cooperativity in the nitrogenase Fe protein electron delivery cycle.

ABSTRACT: Nitrogenase catalyzes the ATP-dependent reduction of dinitrogen (N₂) to two ammonia (NH₃) molecules through the participation of its two protein components, the MoFe and Fe proteins. Electron transfer (ET) from the Fe protein to the catalytic MoFe protein involves a series of synchronized events requiring the transient association of one Fe protein with each αβ half of the α₂β₂ MoFe protein. This process is referred to as the Fe protein cycle and includes binding of two ATP to an Fe protein, association of an Fe protein with the MoFe protein, ET from the Fe protein to the MoFe protein, hydrolysis of the two ATP to two ADP and two P_i for each ET, P_i release, and dissociation of oxidized Fe protein-(ADP)₂ from the M

SUBMITTER: Danyal K 

PROVIDER: S-EPMC5056064 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature