Striosome-dendron bouquets highlight a unique striatonigral circuit targeting dopamine-containing neurons.

ABSTRACT: The dopamine systems of the brain powerfully influence movement and motivation. We demonstrate that striatonigral fibers originating in striosomes form highly unusual bouquet-like arborizations that target bundles of ventrally extending dopamine-containing dendrites and clusters of their parent nigral cell bodies. Retrograde tracing showed that these clustered cell bodies in turn project to the striatum as part of the classic nigrostriatal pathway. Thus, these striosome-dendron formations, here termed "striosome-dendron bouquets," likely represent subsystems with the nigro-striato-nigral loop that are affected in human disorders including Parkinson's disease. Within the bouquets, expansion microscopy resolved many individual striosomal fibers tightly intertwined with the dopamine-containin

SUBMITTER: Crittenden JR 

PROVIDER: S-EPMC5056098 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature