Long-term Follow-up of Patients With Retinitis Pigmentosa Receiving Intraocular Ciliary Neurotrophic Factor Implants.

ABSTRACT:

Purpose

To evaluate the long-term efficacy of ciliary neurotrophic factor delivered via an intraocular encapsulated cell implant for the treatment of retinitis pigmentosa.

Design

Long-term follow-up of a multicenter, sham-controlled study.

Methods

Thirty-six patients at 3 CNTF4 sites were randomly assigned to receive a high- or low-dose implant in 1 eye and sham surgery in the fellow eye. The primary endpoint (change in visual field sensitivity at 12 months) had been reported previously. Here we measure long-term visual acuity, visual field, and optical coherence tomography (OCT) outcomes in 24 patients either retaining or explanting the device at 24 months relative to sham-treated eyes.

Results

Eyes retaining the implant showed significantly greater visual fie

SUBMITTER: Birch DG 

PROVIDER: S-EPMC5056139 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature