Liver and Kidney on Chips: Microphysiological Models to Understand Transporter Function.

ABSTRACT: Because of complex cellular microenvironments of both the liver and kidneys, accurate modeling of transport function has remained a challenge, leaving a dire need for models that can faithfully recapitulate both the architecture and cell-cell interactions observed in vivo. The study of hepatic and renal transport function is a fundamental component of understanding the metabolic fate of drugs and xenobiotics; however, there are few in vitro systems conducive for these types of studies. For both the hepatic and renal systems, we provide an overview of the location and function of the most significant phase I/II/III (transporter) of enzymes, and then review current in vitro systems for the suitability of a transporter function study and provide details on microphysiological systems that lead

SUBMITTER: Chang SY 

PROVIDER: S-EPMC5056140 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature