'Cytology-on-a-chip' based sensors for monitoring of potentially malignant oral lesions.

ABSTRACT:

Unlabelled

Despite significant advances in surgical procedures and treatment, long-term prognosis for patients with oral cancer remains poor, with survival rates among the lowest of major cancers. Better methods are desperately needed to identify potential malignancies early when treatments are more effective.

Objective

To develop robust classification models from cytology-on-a-chip measurements that mirror diagnostic performance of gold standard approach involving tissue biopsy.

Materials and methods

Measurements were recorded from 714 prospectively recruited patients with suspicious lesions across 6 diagnostic categories (each confirmed by tissue biopsy -histopathology) using a powerful new 'cytology-on-a-chip' approach capable of executing high content analysis at

SUBMITTER: Abram TJ 

PROVIDER: S-EPMC5056560 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature