Early-life gut microbiome composition and milk allergy resolution.

ABSTRACT:

Background

Gut microbiota may play a role in the natural history of cow's milk allergy.

Objective

We sought to examine the association between early-life gut microbiota and the resolution of cow's milk allergy.

Methods

We studied 226 children with milk allergy who were enrolled at infancy in the Consortium of Food Allergy observational study of food allergy. Fecal samples were collected at age 3 to 16 months, and the children were followed longitudinally with clinical evaluation, milk-specific IgE levels, and milk skin prick test performed at enrollment, 6 months, 12 months, and yearly thereafter up until age 8 years. Gut microbiome was profiled by 16s rRNA sequencing and microbiome analyses performed using Quantitative Insights into Microbial Ecology (QIIME), Phyloge

SUBMITTER: Bunyavanich S 

PROVIDER: S-EPMC5056801 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature