Eosinophil production of prostaglandin D₂ in patients with aspirin-exacerbated respiratory disease.

ABSTRACT:

Background

Aspirin-exacerbated respiratory disease (AERD) differs from aspirin-tolerant disease in part because of eosinophilic tissue infiltration and overexpression of arachidonic acid metabolic pathway components that lead to enhanced secretion of cysteinyl leukotrienes and prostaglandin (PG) D₂ observed constitutively and paradoxically in response to aspirin and other COX inhibitors. We have previously demonstrated the capacity of IFN-γ to drive cysteinyl leukotriene expression and response.

Objective

We investigated eosinophils as a source of PGD₂ production in patients with AERD.

Methods

Eosinophils were enriched from tissue and peripheral blood obtained from control subjects, patients with aspirin-tolerant disease, and patients with AERD.

SUBMITTER: Feng X 

PROVIDER: S-EPMC5056805 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature