IL-22 derived from γδ T cells restricts Staphylococcus aureus infection of mechanically injured skin.

ABSTRACT:

Background

Staphylococcus aureus is an opportunistic pathogen that colonizes the skin of patients with atopic dermatitis (AD) and aggravates their disease. Neutrophils and the cytokines IL-17A and IL-17F, which drive the expression of the neutrophil-attracting chemokines, are important for the clearance of S aureus infection. The cytokine IL-22 is often coproduced by IL-17-secreting cells. The levels of IL-22 are elevated in AD skin lesions.

Objective

We sought to determine the role of IL-22 in the clearance of S aureus infection of mouse skin subjected to tape stripping, a surrogate for scratching, a cardinal feature of AD.

Methods

S aureus was applied to the tape-stripped skin of wild-type and Il22^-/- mice. Bacterial burden was evaluated by enumerating co

SUBMITTER: Malhotra N 

PROVIDER: S-EPMC5056816 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature