Maternal prenatal fish consumption and cognition in mid childhood: Mercury, fatty acids, and selenium.

ABSTRACT:

Background

Few studies of maternal prenatal fish intake have included biomarkers of exposure to mercury, long-chain n-3 fatty acids, and selenium, which are hypothesized to mediate associations with child neurodevelopment.

Objectives

Examine associations of maternal prenatal fish intake with child neurodevelopment accounting for biomarkers.

Methods

In 1999-2002 we enrolled pregnant women into the Project Viva cohort. At median 27.9weeks gestation, we estimated maternal fish intake using food frequency questionnaires, and collected blood. We assayed erythrocytes for total mercury and selenium, and plasma for fatty acids including n-3 docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). In mid-childhood (median 7.7years), we administered cognitive tests including

SUBMITTER: Oken E 

PROVIDER: S-EPMC5056822 | biostudies-literature | 2016 Sep - Oct

REPOSITORIES: biostudies-literature