Early-life seizures alter synaptic calcium-permeable AMPA receptor function and plasticity.

ABSTRACT: Calcium (Ca²⁺)-mediated⁴ signaling pathways are critical to synaptic plasticity. In adults, the NMDA glutamate receptor (NMDAR) represents a major route for activity-dependent synaptic Ca²⁺ entry. However, during neonatal development, when synaptic plasticity is particularly high, many AMPA glutamate receptors (AMPARs) are also permeable to Ca²⁺ (CP-AMPAR) due to low GluA2 subunit expression, providing an additional route for activity- and glutamate-dependent Ca²⁺ influx and subsequent signaling. Therefore, altered hippocampal Ca²⁺ signaling may represent an age-specific pathogenic mechanism. We thus aimed to assess Ca²⁺ responses 48h after hypoxia-induced neonatal seizures (HS) in postnatal day (P)10 rats, a post

SUBMITTER: Lippman-Bell JJ 

PROVIDER: S-EPMC5056834 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature