Long-chain monounsaturated fatty acid-rich fish oil attenuates the development of atherosclerosis in mouse models.

ABSTRACT:

Scope

Fish oil-derived long-chain monounsaturated fatty acids (LCMUFA) containing chain lengths longer than 18 were previously shown to improve cardiovascular disease risk factors in mice. However, it is not known if LCMUFA also exerts anti-atherogenic effects. The main objective of the present study was to investigate the effect of LCMUFA on the development of atherosclerosis in mouse models.

Methods and results

LDLR-KO mice were fed Western diet supplemented with 2% (w/w) of either LCMUFA concentrate, olive oil, or not (control) for 12 wk. LCMUFA, but not olive oil, significantly suppressed the development of atherosclerotic lesions and several plasma inflammatory cytokine levels, although there were no major differences in plasma lipids between the three groups. At higher

SUBMITTER: Yang ZH 

PROVIDER: S-EPMC5056854 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature