Association of GBA Mutations and the E326K Polymorphism With Motor and Cognitive Progression in Parkinson Disease.

ABSTRACT:

Importance

Parkinson disease (PD) is heterogeneous in symptom manifestation and rate of progression. Identifying factors that influence disease progression could provide mechanistic insight, improve prognostic accuracy, and elucidate novel therapeutic targets.

Objective

To determine whether GBA mutations and the E326K polymorphism modify PD symptom progression.

Design, setting, and participants

The entire GBA coding region was screened for mutations and E326K in 740 patients with PD enrolled at 7 sites from the PD Cognitive Genetics Consortium. Detailed longitudinal motor and cognitive assessments were performed with patients in the on state.

Main outcomes and measures

Linear regression was used to test for an association between GBA genotype and motor progress

SUBMITTER: Davis MY 

PROVIDER: S-EPMC5056861 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature