Recapitulation of Candidate Systemic Lupus Erythematosus-Associated Variants in Koreans.

ABSTRACT: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that affects multiple organ systems. Although the etiology of SLE remains unclear, it is widely accepted that genetic factors could be involved in its pathogenesis. A number of genome-wide association studies (GWASs) have identified novel single-nucleotide polymorphisms (SNPs) associated with the risk of SLE in diverse populations. However, not all the SNP candidates identified from non-Asian populations have been validated in Koreans. In this study, we aimed to replicate the SNPs that were recently discovered in the GWAS; these SNPs have not been validated in Koreans or have only been replicated in Koreans with an insufficient sample size to conclude any association. For this, we selected five SNPs (rs1801274 in FCGR2A<

SUBMITTER: Kwon KS 

PROVIDER: S-EPMC5056901 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature