Nicotinamide-N-Methyltransferase gene rs694539 variant and migraine risk.

ABSTRACT:

Background

Migraine is a common neurovascular disorder affecting 10 to 20 % of the world population usually subdivided into migraine with auro (MA) and migraine without auro (MO). Homocysteine is involved in the pathophysiology of a number of neurological disorders. Elevated levels of homocysteine in the plasma is produced by the MTHFR gene rs 1801133 and rs 1801131 variants as well as the NNMT gene rs 694539 variant.

Methods

With the polymerase chain reaction-restriction fragment length polymorphism method developed recently in our laboratory, we were able to show an association between the NNMT gene rs694539 variant and migraine for the first time.

Results

Here we report the association of the Nicotinamide-N-methyltransferase gene (NNMT) rs694539 variant with migrai

SUBMITTER: Sazci A 

PROVIDER: S-EPMC5056911 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature