Insulin resistance in prepubertal obese children correlates with sex-dependent early onset metabolomic alterations.

ABSTRACT:

Background

Insulin resistance (IR) is usually the first metabolic alteration diagnosed in obese children and the key risk factor for development of comorbidities. The factors determining whether or not IR develops as a result of excess body mass index (BMI) are still not completely understood.

Objectives

This study aimed to elucidate the mechanisms underpinning the predisposition toward hyperinsulinemia-related complications in obese children by using a metabolomic strategy that allows a profound interpretation of metabolic profiles potentially affected by IR.

Methods

Serum from 60 prepubertal obese children (30 girls/30 boys, 50% IR and 50% non-IR in each group, but with similar BMIs) were analyzed by using liquid chromatography-mass spectrometry, gas chromatography-

SUBMITTER: Mastrangelo A 

PROVIDER: S-EPMC5056960 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature