Bone marrow-derived macrophages distinct from tissue-resident macrophages play a pivotal role in Concanavalin A-induced murine liver injury via CCR9 axis.

ABSTRACT: The fundamental mechanism how heterogeneous hepatic macrophage (Mφ) subsets fulfill diverse functions in health and disease has not been elucidated. We recently reported that CCR9⁺ inflammatory Mφs play a critical role in the course of acute liver injury. To clarify the origin and differentiation of CCR9⁺Mφs, we used a unique partial bone marrow (BM) chimera model with liver shielding for maintaining hepatic resident Mφs. First, irradiated mice developed less liver injury with less Mφs accumulation by Concanavalin A (Con A) regardless of liver shielding. In mice receiving further BM transplantation, CD11b^lowF4/80^high hepatic-resident Mφs were not replaced by transplanted donors under steady state, while under inflammatory state by Con A, CCR9

SUBMITTER: Amiya T 

PROVIDER: S-EPMC5057133 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature