Transcranial alternating current stimulation affects the BOLD signal in a frequency and task-dependent manner.

ABSTRACT: Transcranial alternating current stimulation (tACS) has emerged as a promising tool for manipulating ongoing brain oscillations. While previous studies demonstrated frequency-specific effects of tACS on diverse cognitive functions, its effect on neural activity remains poorly understood. Here we asked how tACS modulates regional fMRI blood oxygenation level dependent (BOLD) signal as a function of frequency, current strength, and task condition. TACS was applied over the posterior cortex of healthy human subjects while the BOLD signal was measured during rest or task conditions (visual perception, passive video viewing and motor task). TACS was applied in a blockwise manner at different frequencies (10, 16, 60 and 80 Hz). The strongest tACS effects on BOLD activity were observed with stimu

SUBMITTER: Cabral-Calderin Y 

PROVIDER: S-EPMC5057312 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature