CCL18 from tumor-cells promotes epithelial ovarian cancer metastasis via mTOR signaling pathway.

ABSTRACT: CCL18 is a chemotactic cytokine involved in the pathogenesis and progression of various disorders, including cancer. Previously, our results showed high levels of CCL18 in the serum of epithelial ovarian carcinoma patients suggesting its potential as a circulating biomarker. In this study, we determined that CCL18 expression was up-regulated in ovarian carcinoma compared with adjacent tissue and was expressed in carcinoma cells in the tumor and not in normal ovarian epithelial cells by laser capture microdissection coupled with real-time RT-PCR. Moreover, correlation analysis showed that the CCL18 level was positively correlated with the metastasis of patients with ovarian cancer. Survival analysis also revealed that an increased level of CCL18 was associated with worse survival time in ov

SUBMITTER: Wang Q 

PROVIDER: S-EPMC5057350 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature