Systematic analysis of the polyphenol metabolome using the Phenol-Explorer database.

ABSTRACT:

Scope

The Phenol-Explorer web database details 383 polyphenol metabolites identified in human and animal biofluids from 221 publications. Here, we exploit these data to characterize and visualize the polyphenol metabolome, the set of all metabolites derived from phenolic food components.

Methods and results

Qualitative and quantitative data on 383 polyphenol metabolites as described in 424 human and animal intervention studies were systematically analyzed. Of these metabolites, 301 were identified without prior enzymatic hydrolysis of biofluids, and included glucuronide and sulfate esters, glycosides, aglycones, and O-methyl ethers. Around one-third of these compounds are also known as food constituents and corresponded to polyphenols absorbed without further metabolism. Man

SUBMITTER: Rothwell JA 

PROVIDER: S-EPMC5057353 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature