The whole genome sequences and experimentally phased haplotypes of over 100 personal genomes.

ABSTRACT:

Background

Since the completion of the Human Genome Project in 2003, it is estimated that more than 200,000 individual whole human genomes have been sequenced. A stunning accomplishment in such a short period of time. However, most of these were sequenced without experimental haplotype data and are therefore missing an important aspect of genome biology. In addition, much of the genomic data is not available to the public and lacks phenotypic information.

Findings

As part of the Personal Genome Project, blood samples from 184 participants were collected and processed using Complete Genomics' Long Fragment Read technology. Here, we present the experimental whole genome haplotyping and sequencing of these samples to an average read coverage depth of 100X. This is approximately

SUBMITTER: Mao Q 

PROVIDER: S-EPMC5057367 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature