Essential gene profiles in breast, pancreatic, and ovarian cancer cells.

ABSTRACT:

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Genomic analyses are yielding a host of new information on the multiple genetic abnormalities associated with specific types of cancer. A comprehensive description of cancer-associated genetic abnormalities can improve our ability to classify tumors into clinically relevant subgroups and, on occasion, identify mutant genes that drive the cancer phenotype ("drivers"). More often, though, the functional significance of cancer-associated mutations is difficult to discern. Genome-wide pooled short hairpin RNA (shRNA) screens enable global identification of the genes essential for cancer cell survival and proliferation, providing a "functional genomic" map of human cancer to complement genomic studies. Using a lentiviral shRNA library targeting ~16,000 genes and a newly devel

SUBMITTER: Marcotte R 

PROVIDER: S-EPMC5057396 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature