Research and Development of Hepatitis B Drugs: An Analysis Based on Technology Flows Measured by Patent Citations.

ABSTRACT: Despite the existence of available therapies, the Hepatitis B virus infection continues to be one of the most serious threats to human health, especially in developing countries such as China and India. To shed light on the improvement of current therapies and development of novel anti-HBV drugs, we thoroughly investigated 212 US patents of anti-HBV drugs and analyzed the technology flow in research and development of anti-HBV drugs based on data from IMS LifeCycle databases. Moreover, utilizing the patent citation method, which is an effective indicator of technology flow, we constructed patent citation network models and performed network analysis in order to reveal the features of different technology clusters. As a result, we identified the stagnant status of anti-HBV drug development

SUBMITTER: Huang C 

PROVIDER: S-EPMC5058496 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature