Cell-Type Specific Responses to DNA Replication Stress in Early C. elegans Embryos.

ABSTRACT: To better understand how the cellular response to DNA replication stress is regulated during embryonic development, we and others have established the early C. elegans embryo as a model system to study this important problem. As is the case in most eukaryotic cell types, the replication stress response is controlled by the ATR kinase in early worm embryos. In this report we use RNAi to systematically characterize ATR pathway components for roles in promoting cell cycle delay during a replication stress response, and we find that these genetic requirements vary, depending on the source of stress. We also examine how individual cell types within the embryo respond to replication stress, and we find that the strength of the response, as defined by duration of cell cycle delay, varies dramatic

SUBMITTER: Stevens H 

PROVIDER: S-EPMC5058509 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature