Early Transcriptomic Response to LDL and oxLDL in Human Vascular Smooth Muscle Cells.

ABSTRACT:

Background

Although nowadays it is well known that the human transcriptome can importantly vary according to external or environmental condition, the reflection of this concept when studying oxidative stress and its direct relationship with gene expression profiling during the process of atherogenesis has not been thoroughly achieved.

Objective

The ability to analyze genome-wide gene expression through transcriptomics has shown that the genome responds dynamically to diverse stimuli. Here, we describe the transcriptome of human vascular smooth muscle cells (hVSMC) stimulated by native and oxidized low-density lipoprotein (nLDL and oxLDL respectively), with the aim of assessing the early molecular changes that induce a response in this cell type resulting in a transcriptomic

SUBMITTER: Damian-Zamacona S 

PROVIDER: S-EPMC5058556 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature