Orthostatic Hypotension and the Long-Term Risk of Dementia: A Population-Based Study.

ABSTRACT:

Background

Orthostatic hypotension (OH) is a common cause of transient cerebral hypoperfusion in the population. Cerebral hypoperfusion is widely implicated in cognitive impairment, but whether OH contributes to cognitive decline and dementia is uncertain. We aimed to determine the association between OH and the risk of developing dementia in the general population.

Methods and findings

Between 4 October 1989 and 17 June 1993, we assessed OH in non-demented, stroke-free participants of the population-based Rotterdam Study. OH was defined as a ≥20 mm Hg drop in systolic blood pressure (SBP) or ≥10 mm Hg drop in diastolic blood pressure (DBP) within 3 min from postural change. We furthermore calculated within participant variability in SBP related to postural change, expressed

SUBMITTER: Wolters FJ 

PROVIDER: S-EPMC5058559 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature