Novel diagnostic and prognostic classifiers for prostate cancer identified by genome-wide microRNA profiling.

ABSTRACT:

Purpose

This study investigates the diagnostic and prognostic biomarker potential of miRNAs in prostate cancer (PC).

Results

We identified several new deregulated miRNAs between non-malignant (NM) and PC tissue samples and between more/less aggressive PC subgroups. We also developed and validated a novel 13-miRNA diagnostic classifier with high sensitivity and specificity for PC. Finally, we trained a new 3-miRNA prognostic classifier (miR-185-5p+miR-221-3p+miR-326) that predicted time to biochemical recurrence (BCR) independently of routine clinicopathological variables in a training radical prostatectomy (RP) cohort (n = 126) as well as in two independent validation cohorts (n = 110 and n = 99).

Experimental design

After RT-qPCR-based profiling of 752 miRNAs in 13 N

SUBMITTER: Kristensen H 

PROVIDER: S-EPMC5058715 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature