Genetic Variations in Key MicroRNAs are Associated With the Survival of Nonsmall Cell Lung Cancer.

ABSTRACT: MicroRNAs (miRNAs) are a class of small, noncoding RNA molecules involved in carcinogenesis. It has been identified that genetic variations in miRNAs contribute to cancer risk, prognosis, and survival. In the present study, we investigated whether single nucleotide polymorphisms (SNPs) of several key miRNAs (miR-184, miR-218, and miR-124) were associated with the prognosis of nonsmall cell lung cancer (NSCLC) in a clinical cohort study including 1001 cases. Cox proportional hazards regression models were used to estimate the hazard ratios (HRs) and their 95% confidence intervals (CIs). We found that 5 SNPs were associated with NSCLC survival (rs919968, rs3775815, rs4867902, and rs6122390 in an additive model: adjusted HR = 1.15, 95% CI = 1.02-1.29; adjusted HR = 0.78, 95% CI = 0.67-0.91, a

SUBMITTER: Wu S 

PROVIDER: S-EPMC5058987 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature